(Lab required) Topics will include the definition and history of microbiology, concepts of practical microbiology, prokaryotic cell structure, prokaryotic specialization in gene expression and transfer of genetic information, the role of microbes in environments including the human body, and applications of microbiology to food production and biotechnology. May not be held with MBIO 1011.

An introduction to the essential principles of microbiology including immunity, with emphasis on microbial disease. Not available to students who have previously obtained credit in or are currently enrolled in MBIO 1010 or MBIO 1011 (or the former MBIO 2100 or MBIO 2101). NOTE: MBIO 1220 is intended for students planning to enter the College of Nursing or other health care or related programs. Students that have completed MBIO 1010 but wish to take MBIO 1220 to satisfy Faculty of Nursing entrance requirements must obtain departmental permission prior to registering for MBIO 1220. MBIO 1220 cannot be used to satisfy the requirements of the Microbiology Honours or Major degree programs. MBIO 1220 can be used as an elective course in any Science program.

An introduction to the mechanisms, themes and patterns that are present in the molecular biology of organisms ranging from bacteria to humans. The basic applications of molecular biology to disciplines such as medical microbiology, criminology, genetic fingerprinting, genome sequencing, and bioinformatics will be discussed. NOTE: MBIO 1410 is intended for students outside of Microbiology and Biological Sciences who require an introduction to molecular biology, such as those with interests in bioinformatics, biophysics, or bioengineering. Although this course may be used as an elective in an Arts or Science program, it may not be used to meet a program requirement for an Honours or Major program in Microbiology. Not available to students who have previously obtained credit in, or are currently enrolled in the following courses: the former MBIO 2410, BIOL 2500, BIOL 2501, MBIO 2020, MBIO 2021, the former MBIO 2100, MBIO 2101, MBIO 3410 or MBIO 3411.

(Lab required) Topics will include bacterial growth, chromosome replication, the specifics of transcription and translation and their application to the regulation of microbial gene expression. Families of bacterial and animal viruses, their modes of reproduction and pathogenicity will be discussed. Mutation and gene transfer in bacteria will be introduced. May not be held with MBIO 2021, the former MBIO 2110, or the former MBIO 2111.

The roles and interactions of biological, chemical and geological reactions in determining the composition of the environment. Microorganisms as major agents of biogeochemical change and their roles in the element cycles will be especially emphasized.

An introduction to the general principles of eukaryotic virology, with emphasis on animal virus systems. These principles will be reinforced and expanded to deal with specific viruses that cause acute and chronic infections in humans. Topics to be discussed include the molecular structure of viruses; the basic multiplication strategies of the major virus families; mechanisms of host immune evasion and viral latency, persistence, and oncology.

An introductory course dealing with the kinds of molecules encountered in biochemistry, and the concept of metabolic energy as a product of catabolism and a requirement for biosynthesis. Also offered as CHEM 2700. May not be held with the former MBIO 2360, the former MBIO 2361, MBIO 2701, MBIO 2730, the former MBIO 2770, the former CHEM 2360, the former CHEM 2361, CHEM 2700, CHEM 2701, CHEM 2730, the former CHEM 2860, or the former CHEM 2770.

An introductory course dealing with the basic metabolic processes that occur in living cells, including the production and use of metabolic energy, the breakdown and synthesis of biomolecules; the synthesis of DNA, RNA and proteins; and the regulation of these processes. Also offered as CHEM 2710. May not be held with the former MBIO 2370, the former MBIO 2371, MBIO 2711, MBIO 2750, the former MBIO 2780, the former CHEM 2370, the former CHEM 2371, CHEM 2710, CHEM 2711, CHEM 2750, or the former CHEM 2780.

Basic concepts of biochemistry including the properties of biomolecules (amino acids and proteins, enzymes, carbohydrates, lipids, and nucleic acids) and aspects of energy production in cells. Primarily for students in Agricultural and Food Sciences and four-year Biological Sciences programs in Science. May not be used as part of an Honours, Major, or Minor program in Chemistry. May not be used as part of an Honours or Major program in Microbiology. This course is also given in Chemistry as CHEM 2730. May not be held with the former CHEM 2360, the former CHEM 2361, CHEM 2700, CHEM 2701, CHEM 2730, the former CHEM 2770, the former CHEM 2860, the former MBIO 2360, the former MBIO 2361, MBIO 2700, MBIO 2701, or the former MBIO 2770.

The continuation of CHEM 2730/MBIO 2730, dealing with nitrogen and lipid metabolism, representative biosynthetic pathways, and synthesis and importance of DNA, RNA and proteins. Primarily for students in Agricultural and Food Sciences and four-year Biological Sciences programs in Science. May not be used as part of an Honours, Major, or Minor program in Chemistry. May not be used as part of an Honours or Major program in Microbiology. This course is also given in Chemistry as CHEM 2750. May not be held with the former CHEM 2370, the former CHEM 2371, CHEM 2710, CHEM 2711, CHEM 2750, the former CHEM 2780, the former MBIO 2370, the former MBIO 2371, MBIO 2710, MBIO 2711, or the former MBIO 2780.

A comprehensive overview of applied biological safety in research and industrial environments and the disease-causing features of relevant infectious agents and considerations for their containment.

A consideration of host-parasite relationships, an introduction to the immune response, microbial pathogenesis, viral diseases, clinical microbiology and public health, and an introduction to antimicrobial agents. May not be held with MBIO 3011.

The course will include an introduction to microbial growth and genomics approaches used for the analysis of microbial metabolism. Using these tools, the physiology of microbial cell walls, transport, and motility, as well as microbial metabolism as related to ATP production, respiration, fermentation and carbon fixation will be discussed. May not be held with the former MBIO 3030, the former MBIO 3031, or MBIO 3033.

The course will examine microbial communities, which will be discussed in terms of their composition, physiological adaptations and their effects on their abiotic and biological surroundings. Topics will include nutrient cycling, biodegradation and adaptation to extreme environments, and the applications arising from these microbial functions. Methods for quantitation of microbial biomass and biological activity will be discussed. May not be held with MBIO 3283, the former MBIO 2280, or the former MBIO 3280.

A rigorous treatment of the foundations of modern day molecular biology as it pertains to molecular disease, gene and cell manipulation, and cellular controls. May not be held with MBIO 3411.

An analysis starting with prebiotic evolution, progressing through the elaboration of macromolecules and examining their adaptation to their function as cellular components. Proteins, carbohydrates, and nucleic acids as structural, catalytic, and genetic elements in evolution of living systems.

Mechanisms of regulation of enzyme activity, including allostery, control of selected biosynthetic and degradative pathways and regulation of gene expression. May not be held with MBIO 3451.

(Lab required) Isolation, fractionation, structure and function of cellular membranes and subcellular components. The central role of these elements in the biochemistry of cellular processes will be stressed. May not be held with MBIO 3461.

Characterization and classification of the major group of micro-organisms. Bases for divisions and the relatedness among organisms will be studied. May not be held with the former MBIO 3470.

A laboratory-based course, intended to teach the fundamental techniques required to work in a modern molecular microbiology laboratory. Students will develop a thorough understanding of the theory underpinning the techniques introduced in this course, laboratory skills in current molecular microbiology techniques, and application of techniques to investigate scientific questions, such as the identification of unknowns. Learning outcomes include development of technical skills, competency in following protocols, presentation of results and scientific writing. May not be held with MBIO 3601, the former MBIO 4600, the former MBIO 4601, or MBIO 4030 when titled Advanced Microbial Genetics Lab.

This lab course will introduce students to the morphological and physiological study of microorganisms. Students will reinforce their basic lab skills while carrying out discovery-based experiments involving microscopy, antibiotic susceptibility testing, bacterial enumeration, physiology and identification. May not be held with the former MBIO 3030 or the former MBIO 3031.

Work assignments in business, industry or government for students registered in the Microbiology Honours or Major Cooperative program. Requires submission of a written report covering the work completed during the four-month professional assignment. (Pass/Fail grade only).

Work assignments in business, industry or government for students registered in the Microbiology Honours or Major Cooperative program. Requires submission of a written report covering the work completed during the four-month professional assignment. (Pass/Fail grade only).

Topics will include antigens, antibodies, antigen-antibody reactions, immunogenetics, regulation of immune reactions, complement, hypersensitivities, autoimmunity, immunodeficiencies, transplantation and tumour immunology. May not be held with the former MBIO 4010, the former MBIO 4011, or MBIO 4021.

Microbiology is a very broad field that encompasses a wide range of specialized topics. In this course, students can pursue a specific topic in detail through lectures, assigned readings, seminars and research projects. The course is normally restricted to third and fourth year Honours and Major students. Topics to be covered by the course shall be decided by the instructor(s) in consultation with the student(s) and with the approval from the Department. Grades are based on written assignments and reports. Evaluation may also include oral presentation and poster presentation(s).

(Lab required) Microbiology is a very broad field that encompasses a wide range of specialized topics. In this course, students can pursue a specific topic in detail through laboratory-based research projects and may include lectures, assigned readings, and presentation of seminars. The course is normally restricted to third and fourth year Honours and Major students in Microbiology, Biochemistry, and Genetics. Topics to be covered by the course shall be decided by the instructor(s) in consultation with the student(s) and with the approval from the Department.

This course will build upon MBIO 3010. The course will cover the different influential factors such as climate, travel, poverty and socio-economic conditions, government and religion, and how they impact the prevention, spread and treatment of key infectious disease in different parts of the world. May not be held with MBIO 4030 when titled Infectious Diseases around the World.

A comprehensive examination of fundamental properties of viruses, virus taxonomy, and the different ways in which viruses replicate. The ways viruses cause disease and experimental methods used in virology also will be examined. May not be held with MBIO 4411.

(Lab required) Systems microbiology integrates physiological information and functional genomics (genomics, transcriptomics, proteomics, metabolomics) data, as well as large scale mutagenesis and chemogenomics to create models of the complex interactions within microbial cells to understand how a bacterial cell functions as an integrated whole. Applications to more complex microbial communities will also be discussed. May not be held with the former MBIO 4440.

(Lab required) A course investigating the diversity of roles microbes play in our immediate environment, and how they affect it. Environments to be examined may include the human body, waste treatment facilities and extreme environments. Molecular tools to study the community structure and roles of individual organisms will also be discussed. May not be held with the former MBIO 3480 or the former MBIO 4320.

(Lab required) The course will cover bioprocesses for a range of commercially important healthcare and industrial products. Topics will also include bioreactor design and control for these bioprocesses, metabolic engineering for product enhancement, applied engineering and downstream processing. May not be held for credit with the former MBIO 4510.

(Lab required) A research project chosen in consultation with the course administrator and supervised by a faculty member. A written report is normally required. The course is available only to final year Honours students in Microbiology, Biochemistry, or the Genetics program. May not be held with CHEM 4710, CHEM 4711, MBIO 4531, or BGEN 4010.

Biochemistry of biological processes involving interconversion of different forms of energy such as oxidative phosphorylation, membrane transport and contractile processes. May not be held with MBIO 4541. MBIO 3032, MBIO 3033, the former MBIO 3030, or the former MBIO 3031 is recommended as a prerequisite to this course.

A detailed examination of genetic mechanisms of replication, expression, mutability, repair and transposition of DNA in bacteria and their viruses, and their applications in recombinant DNA technology. The contribution of these genetic mechanisms to virulence in bacterial pathogens will also be examined. May not be held with MBIO 4603, the former MBIO 4600, or the former MBIO 4601.

A comprehensive study dealing with replication and expression of DNA, genome structure, and the involvement of genes in diseases such as cancer. May not be held with MBIO 4613 or the former MBIO 4610.

The overall objective of this course is to introduce and describe the current molecular techniques and their application to biological problems. These include, but are not limited to, basic gene cloning, mutagenesis and over-expression. May not be held with the former MBIO 4570, MBIO 4670, the former MBIO 4580, MBIO 4581.

The introduction to bioinformatics concepts achieved by applying computational tools to analyse sequence/molecular data relevant to Microbiology. The course will introduce existing bioinformatics tools that deal with biological databases, sequence alignment, gene and protein structure prediction, molecular phylogenetics, genomics and proteomlcs. May not be held with MBIO 4030 when the topic was Applied Bioinformatics Resources for Microbial Based Research.

Work assignments in business, industry or government for students registered in the Microbiology Honours or Major Cooperative program. Requires submission of a written report covering the work completed during the four-month professional assignment. (Pass/Fail grade only).

Work assignments in business, industry or government for students registered in the Microbiology Honours or Major Cooperative program. Requires submission of a written report covering the work completed during the four-month professional assignment. (Pass/Fail grade only).