Pharmacology and Therapeutics, Ph.D.

Pharmacology and Therapeutics
Head: Chris Anderson
Campus Address/General Office: A205 Chown Building, 753 McDermot Avenue, Winnipeg, MB, R3E 0T6
Telephone: 204-789-3553
Email Address: pharmacology@umanitoba.ca
Website: umanitoba.ca/medicine/department-pharmacology-and-therapeutics
Academic Staff: Please refer to the Pharmacology and Therapeutics website for Academic staff information.

Pharmacology and Therapeutics Program Information

The department offers both Master of Science and Doctor of Philosophy degrees. A joint M.D.-Ph.D. program is available to students in Medicine.

Admission Information

Admission to the Faculty of Graduate Studies

Application and Admission Procedures are found in the Academic Guide.

Admission requirements for doctoral students are found in the Doctor of Philosophy General Regulations section of the Guide.

Pharmacology and Therapeutics Ph.D. Admission Requirements

Students with a research based M.Sc. degree in a related field (Science, Pharmacy, and Nursing) may be admitted directly into the Ph.D. Program. Students with a B.Sc. (Hons) degree (or 4-year equivalent) and no graduate degree will first be admitted to the M.Sc. Program.

If recommended by the Advisory Committee and the Department Graduate Committee, an M.Sc. student may be encouraged to apply for transition into the Ph.D. Program. Students with an M.Sc. in an unrelated field will be evaluated on an individual basis.

Application Information

Students should complete and submit their online application with supporting documentation by the date indicated on the Pharmacology and Therapeutics Ph.D. program of study page.

Degree Requirements

Course requirements will depend on prior degree held and research experience. Entry with a B.Sc. (Hon) degree (or four year equivalent) may require a course schedule similar to that described for the M.Sc. degree. Students entering with a graduate degree (M.Sc.) will have a course schedule that is dependent on previous course work.

Expected Time to Graduate: 3 – 5 years

Progression Chart

Plan of Study Grid
Year 1		Hours
GRAD 7300	Research Integrity Tutorial	0
GRAD 7500	Academic Integrity Tutorial	0
PHAC 7136	General Pharmacology	3
COURSE 7XXX	Approved coursework at the 7000 level ¹	0-3
	Hours	3-6
Year 2
PHAC 7222	Molecular Pharmacology 2	3
COURSE 7XXX	Approved coursework at the 7000 level	0-3
GRAD 8010	Doctoral Candidacy Examination ¹	0
Thesis Proposal ¹
	Hours	3-6
Years 3-4
GRAD 8000	Doctoral Thesis	0
	Hours	0
	Total Hours	6-12

¹: A written thesis proposal is to be provided to the Advisory Committee at least two weeks prior to the proposal presentation date. The Candidacy Exam and Thesis Proposal must not be more than four weeks apart.

Notes:

Students in the pharmacology M.Sc. program who elect to transfer to the Ph.D. program are required to take 15 credit hours at the 7000 level. Courses taken as part of the M.Sc. program will count toward this requirement.
Students are expected to attend all departmental seminars, M.Sc. and Ph.D. thesis defences, student research presentations and any discussion sessions with visitors to the Department.
Direct entry students in the Ph.D. Program will have an oral exam at the end of the first year of the program.

Registration Information

Students should familiarize themselves with the Faculty of Graduate Studies ‘GRAD’ courses applicable to their program. If you have questions about which GRAD course(s) to register in, please consult your home department/unit.

Prior to registration, all new and returning students must meet with their advisor and Pharmacology Director of Graduate Studies to determine their program of study.

All course additions and withdrawals (registration revisions) must be approved in the same manner.

Regulations

Students must meet the requirements as outlined in both Supplementary Regulation and BFAR documents as approved by Senate.

Supplementary Regulations

Individual units may require specific requirements above and beyond those of the Faculty of Graduate Studies, and students should consult unit supplementary regulations for these specific regulations.

Bona Fide Academic Requirements (BFAR)

Bona Fide Academic Requirements (BFAR) represent the core academic requirements a graduate student must acquire in order to gain, and demonstrate acquisition of, essential knowledge and skills.

All students must successfully complete:

GRAD 7300 prior to applying to any ethics boards which are appropriate to the student’s research or within the student’s first year, whichever comes first; and
GRAD 7500 within the first term of registration;

unless these courses have been completed previously, as per Mandatory Academic Integrity Course and Mandatory Research Integrity Online Course.

Students must also meet additional BFAR requirements that may be specified for their program.

General Regulations

All students must:

maintain a minimum degree grade point average of 3.0 with no grade below C+,
meet the minimum and not exceed the maximum course requirements, and
meet the minimum and not exceed the maximum time requirements (in terms of time in program and lapse or expiration of credit of courses).

Courses

Pharmacology

PHAC 7042 Cardiovascular Regulation and Drug Action 2 1.5 cr

The normal homeostatic regulation of the cardiovascular system, its modification by drugs, and the sites and characteristics of drug actions affecting the cardiovascular system.

PHAC 7062 Drug Distribution, Metabolism and Excretion A 1.5 cr

The mechanisms by which the body handles the absorption, distribution and elimination of drugs and the impact this has on biological response.

PHAC 7064 Drug Distribution, Metabolism and Excretion B 1.5 cr

The mechanisms influencing the absorption, distribution and elimination of drugs from the body and their impact on pharmacodynamic and pharmacokinetic properties.

PR/CR: A minimum grade of C is required unless otherwise indicated.
Prerequisite: PHAC 7062 or its equivalent.

PHAC 7110 Topics in Pharmacology 6 cr

(Formerly 089.711) Short research projects on various properties and effects of newer drugs. Presentation of oral and written reports by graduate students on research conducted. Open only to graduate students in Pharmacology.

PHAC 7136 General Pharmacology 3 cr

General pharmacological principles including pharmacodynamics of the more important groups of drugs, the factors which control and modify their effects, and the basis for rational selection and administration of drugs in the treatment of common diseases.

PR/CR: A minimum grade of C is required unless otherwise indicated.
Prerequisite: permission of department.

PHAC 7162 Neuropharmacology 1.5 cr

A broad sample at the graduate level of the pathophysiology, pharmacological treatments, and current research related to common neurological disorders. These will be didactic lectures followed by discussion of current topics in neuropathology and neuropharmacology.

PHAC 7164 Pharmacology Grant Writing Course 1.5 cr

The objective of this course is to teach students how to formulate, write, and present a professional research grant on the subject of their pharmacology graduate research. Students will be required to write and present a research grant under the close supervision of the course director.

PHAC 7180 Recent Advances in Pharmacology 3 cr

Lectures given by staff, followed by group discussions on current research, new developments in drugs and re-evaluation of currently employed drugs, their mechanism of action, etc. Three hours per week both terms. Open only to graduate students in Pharmacology.

PHAC 7190 Pharmacokinetics of Drug Disposition 3 cr

Lectures and problem-solving sessions directed at appropriate modelling of the disposition of drugs in the body.

PHAC 7212 Clinical Trial A 1.5 cr

Evaluate the essential elements of clinical trials as the basis for determining the potential value of interventions advocated for the treatment of diseases in humans. Topics include designing a study question, types of clinical trial designs, methods for randomization, sample size calculations, and ethics. The format will include assigned readings, lectures, discussion and assignment preparation.

PHAC 7214 Clinical Trial B 1.5 cr

Evaluate the essential elements of clinical trials as the basis for determining the potential value of interventions advocated for the treatment of diseases in humans. Topics include recruitment, baseline assessment, reporting morbidity and mortality, data collection, and survival analysis. While it is suggested that PHAC 7212 is taken before PHAC 7214 since there is a natural progression of information, it is not required that both courses are taken.

PHAC 7222 Molecular Pharmacology 2 3 cr

Lectures, seminars and selected readings on the mechanism of action of therapeutic and recreational drugs. This course covers 6 major themes: G-protein coupled receptors; Ion channels; Transporters; Lipid signaling; Tyrosine kinase receptors and tyrosine kinase-associated receptors.

PHAC 7230 Fundamental in Pharmacology for Health Care I 3 cr

This course will build on foundational knowledge of human physiology and examine basic pharmacokinetic (drug metabolism) and pharmacodynamic (drug action) principles of specific drug classes related to the autonomic nervous system, cardiovascular system (edema, hypertension, arrhythmia, angina, blood clotting, heart failure, hyperlipidemia), diabetes, thyroid, inflammation and pain. Remaining major drug classes will be covered in PHAC 7240. Students may take one or both courses. Taking both courses must be done in the same academic year (Sept to April) or with permission from the Department Head. Course delivery will involve lectures followed by clinical case-based tutorials.

PHAC 7240 Fundamentals in Pharmacology for Health Care II 3 cr

This course will build on foundational knowledge of human physiology and examine basic pharmacokinetic (drug metabolism) and pharmacodynamic (drug action) principles of specific drug classes related to the central nervous system (depression, psychosis, anxiety, epilepsy, movement disorders (e.g. Parkinson's)), infection (bacterial, viral, fungal), cancer, asthma, allergy, osteoporosis, gastrointestinal system, reproduction and special topics (pregnancy, geriatrics, drugs of abuse). Remaining major drug classes will be covered in PHAC 7230. Students may take one or both courses. Taking both courses must be done in the same academic year (Sept to April) or with permission from the Department Head. Course delivery will involve lectures followed by clinical case-based tutorials.

Academic Calendar